Scott Edwards

Veterinary Science

Dr Scott Edwards

BSc BVMS PhD MACVSc

Senior Lecturer in Veterinary Pharmacology
Wagga Wagga
Building 229 Room 106

Scott graduated at Murdoch University a Veterinary Surgeon in 1988. A single year in pig consultancy was then followed by a number of small animal positions, in Australia and the UK. Scott returned to Murdoch University in 2002 as lecturer in pharmacology, attained his PhD in 2008 before moving to CSU in 2009. One day a week in small animal clinics keeps him in touch with the real veterinary world, lest he be completely be swept away into the research alternative universe.

  • Sustained/controlled drug delivery platforms (liposomes, polymer microspheres and alginate gels) for intra-articular (IA) administration of non-steroidal anti-inflammatory drugs (NSAIDs).
  • Alginate gel platforms for delivery of NSAIDs, anti-fungals, hyaluronic acid and antibiotics into the eye and peritoneal cavity.
  • Pharmacokinetics of a range of drugs, primarily in the horse.
  • Potential therapeutics for the prevention/treatment of perennial ryegrass staggers (PRGS) in sheep.
  • Stress associated with management procedures in live stock: potential therapeutics for use in ruminants.
  • Multi-modal analgesia in small animals

Edited Volumes 

Chapter Editor NSAIDs – Merck Veterinary Manual, 2014.

Refereed Journal Articles

  1. Combs MD, Edwards SH, Scherpenhuizen JM, Narayan EJ, Kessell AE, Ramsay J, Piltz J, Raidal SR, Quinn JC (2019). “Treatment with potassium bromide mitigates ataxia and reduces tremor in lambs with perennial ryegrass toxicosis.” N Z Vet J Jul 14:1-8.
  2. Rendle DI, Doran G, Ireland J, Edwards S (2019). “Pharmacokinetics and pharmacodynamics of pergolide mesylate after oral administration in horses with pituitary pars intermedia dysfunction.” Domest Anim Endocrinol Jul;68:135-141.
  3. M.A. Combs, S.H. Edwards, J.M. Scherpenhuizen, E.J. Narayan, A.E. Kessell, J. Piltz, S.R. Raidal, J. Ramsay & J.C. Quinn (2018): “Development of a model for investigation of perennial ryegrass toxicosis in sheep.” NZ Vet J, 2018 Nov;66(6):281-289.
  4. Doran GS, Smith AK, Rothwell JT and Edwards SH (2018). “Direct detection of glucuronide metabolites of lidocaine in sheep urine.” J Chrom B 107684-90.
  5. Robertson SM, Friend MA and Edwards S (2018). “Caffeine supplementation of ewes during lambing may increase lamb survival.” Animal 12(2): 376-382.
  6. Edwards SH, Khalfan SA, Jacobson GA, Pirie AD and Raidal SL (2017). “Pharmacokinetics after intravenous continuous rate infusions of sodium benzyl penicillin and ceftiofur sodium to adult horses” Am J Vet Res Jan;78(1):17-26.
  7. Rendle D I, Hughes K J, Doran G S and Edwards S H (2015). "Pharmacokinetics of pergolide after intravenous administration to horses." Am J Vet Res 76(2): 155-160.
  8. Quast T, Combs M and Edwards S (2015). "Pharmacokinetics of bromide in adult sheep following oral and intravenous administration." Aust Vet J 93

    9. (1-2): 20-25.

  9. Jacobson G A, Pirie A, Edwards S, Hughes K J, Rendle D I and Davies N W (2014). "Determination of pergolide in horse plasma by UPLC-MS/MS for pharmacokinetic applications." J Pharm Biomed Anal 94: 54-57.
  10. Doran G, Hughes K, Rendle D and Edwards S (2013). "The analysis of pergolide residues in horse plasma by LC with fluorescence detection." J AOAC Int 96(6): 1487-1493.
  11. Rendle, D.I., Hughes, K.J., Doran, G. and Edwards, S. (2013), “Pharmacokinetics of Pergolide Mesylate in Horses.” Equine Vet J, 45: 19.
  12. Raidal S L, Edwards S, Pippia J, Boston R and Noble G K (2013). "Pharmacokinetics and safety of oral administration of meloxicam to foals."

    13. J Vet Intern Med 27(2): 300-307.

  13. Noble G, Edwards S, Lievaart J, Pippia J, Boston R and. Raidal S L (2012). "Pharmacokinetics and safety of single and multiple oral doses of meloxicam in adult horses." J Vet Intern Med 26(5): 1192-1201.
  14. Edwards SH (2011) Intra-articular drug delivery: the challenge to extend drug residence time within the joint. Vet J 190, 15-21.
  15. Tinworth KD, Edwards S, Noble GK, Harris PA, Sillence MN, Hackett LP (2010). Pharmacokinetics of metformin after enteral administration in insulin-resistant ponies. Am J Vet Res 71, 1201-1206.
  16. Cake M, Read R, Edwards S, Smith MM, Burkhardt D, Little C, Ghosh P (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. J Orthop Sci 13, 514-523.
  17. Raidal SL, Edwards S (2008). Pharmacokinetics of potassium bromide in adult horses. Aust Vet J 86, 187-193.
  18. Edwards SH, Cake MA, Spoelstra G, Read RA (2007). Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker. J Liposome Res 17, 249-261.

Patents

  1. PCT specification- Prevention and treatment of toxicoses M50078243. In National phase. Co-inventor. Lodged by CSU and Meat and Livestock Australia.
  2. PCT specification- Stress management M50078238. In National phase. Co-inventor. Lodged by CSU. Commercialisation of patent IP is underway.
  3. PCT specification- Livestock supplement and use thereof.  In International phase. Co-inventor. Lodged by CSU.